Comparison of Apoptosis and Terminal Differentiation: The Mammalian Aging Process-Reference-Cited by-同舟云学术

Comparison of Apoptosis and Terminal Differentiation: The Mammalian Aging Process

Published:2001-07 Issue:7 Volume:49 Page:929-930
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Gagna C.E.¹²,Kuo H.-R.²,Florea E.¹,Shami W.¹,Taormina R.¹,Vaswani N.¹,Gupta M.¹,Vijh R.¹,Lambert W.C.²

Affiliation:

1. School of Allied Health & Life Sciences, New York Institute of Technology, Old Westbury, New York

2. Department of Pathology and Laboratory Medicine, University of Medicine & Dentistry of New Jersey-Medical School, Newark, New Jersey

Abstract

Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/002215540104900717

Reference7 articles.

1. Localization of B-DNA and Z-DNA in Terminally Differentiating Fiber Cells in the Adult Lens

2. Apoptosis induced by anticancer drugs

3. Multi-Step Chromatin Degradation in Apoptosis

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