Immunohistochemical Analysis of Advanced Human Breast Carcinomas Reveals Downregulation of Protein Kinase Cα-Reference-Cited by-同舟云学术

Immunohistochemical Analysis of Advanced Human Breast Carcinomas Reveals Downregulation of Protein Kinase Cα

Published:2004-03 Issue:3 Volume:52 Page:419-422
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Kerfoot Christopher¹,Huang Weidong¹,Rotenberg Susan A.²

Affiliation:

1. IMPATH Predictive Oncology, Inc., Los Angeles, California

2. Department of Chemistry & Biochemistry, Queens College of CUNY, Flushing, New York

Abstract

Forty-six advanced-stage human breast carcinoma specimens were evaluated by immunohistochemistry for PKCα expression and compared with 25 samples of normal adjacent breast tissue. For normal tissue, the median staining of ductal epithelia was of moderate intensity. No staining was observed for 67% of tumor specimens, and only 4% showed intensities greater than the median observed in normal tissue. Faint to moderate PKCα staining was observed in the stroma, inflammatory cells, and fibroblasts of tumors but was absent in normal tissue. These findings demonstrate that downregulation of PKCα protein occurs in epithelial cells of advanced breast tumors ( p<0.001).

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/002215540405200314

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