Localization of Thioredoxin-interacting Protein (TXNIP) mRNA in Epithelium of Human Gastrointestinal Tract-Reference-Cited by-同舟云学术

Localization of Thioredoxin-interacting Protein (TXNIP) mRNA in Epithelium of Human Gastrointestinal Tract

Published:2003-07 Issue:7 Volume:51 Page:973-976
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Takahashi Yasuo¹,Ishii Yukimoto²,Murata Akiko¹,Nagata Toshihito¹,Asai Satoshi¹

Affiliation:

1. Division of Genetic and Genomic Medicine, Medical Research Center, Nihon University School of Medicine, Tokyo, Japan

2. 3rd Department of Surgery, Nihon University School of Medicine, Tokyo, Japan

Abstract

Thioredoxin-interacting protein (TXNIP) is a negative regulator of thioredoxin. However, its role in the gastrointestinal (GI) epithelium is as yet unknown. Using in situ hybridization, we demonstrated that mRNA of TXNIP was differentially expressed in the epithelium of the human GI tract. TXNIP transcript was especially prominent in terminal differentiated cells. TXNIP was also highly expressed in lymphocytes in the lymphoid follicles. Our results suggest a new potential role of TXNIP in the differentiation of epithelial cells and in mucosal immunity of the GI tract.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/002215540305100713

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