Cytochemical Localization of Ouabain-sensitive, K+-dependent p-Nitrophenylphosphatase Activity in the Choroid Plexus of Normal and Reserpinized Guinea Pigs

Author:

Dai Chun-Fu1,Kanoh Naoyuki2

Affiliation:

1. Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Shanghai Medical University, Shanghai, P.R. China

2. Department of Otolaryngology, Hyogo College of Medicine, Hyogo, Japan

Abstract

SUMMARY High doses of reserpine induce depletion of biogenic amines. The K-NPPase activity of choroid plexus was determined after one-shot reserpine administration using cerium-based cytochemistry. In normal untreated animals, reaction product was found on the microvilli of the choroidal epithelium but was almost undetectable 3 and 7 days after reserpinization. At 20 days after reserpinization, however, it was detectable. These findings suggested that reserpine decreased the choroidal Na,K-ATPase activity, and that catecholamines might be essential to maintain normal choroidal Na,K-ATPase activity.

Publisher

SAGE Publications

Subject

Histology,Anatomy

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