1. Departments of Anatomy (ER) and Physiology (FT), Medical Faculty, University of Saarland, Homburg/Saar, Germany; School of Biological Sciences, University of Manchester, Manchester, United Kingdom (ER, FT); and Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center and Departments of Medicine and Cell Biology, Harvard Medical School, Boston, Massachusetts (SLA)