Immunolocalization of Sperm Protein 17 in Human Testis and Ejaculated Spermatozoa-Reference-Cited by-同舟云学术

Immunolocalization of Sperm Protein 17 in Human Testis and Ejaculated Spermatozoa

Published:2003-09 Issue:9 Volume:51 Page:1245-1248
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Grizzi Fabio¹²,Chiriva–Internati, Maurizio³,Franceschini Barbara¹²,Hermonat Paul L.⁴,Soda Giuseppe⁵,Lim Seah H.³,Dioguardi Nicola¹³

Affiliation:

1. Scientific Direction, Istituto Clinico Humanitas, Rozzano, Milan, Italy

2. Fondazione “Michele Rodriguez,” Istituto Scientifico per le Misure Quantitative in Medicina, Milan, Italy

3. Texas Tech University Health Science Center, and Don and Sybil Harrington Cancer Center, Amarillo, Texas

4. Division of Obstetrics and Gynecology, University of Arkansas Medical Sciences, Little Rock, Arkansas

5. Department of Experimental Medicine and Pathology, University of Rome “;La Sapienza,” Rome, Italy

Abstract

Sperm protein 17 (Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/002215540305100916

Reference14 articles.

1. Sequence and characterization of the sperm protein Sp17 from the baboon

2. “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

3. Sperm protein 17 (Sp17) in multiple myeloma: opportunity for myeloma-specific donor T cell infusion to enhance graft-versus-myeloma effect without increasing graft-versus-host disease risk

4. A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding

5. Sperm protein 17 is not expressed on normal leukocytes

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Expression of Markers of Semen Quality and Fertility in Stallions of the Crioulo Breed;ACTA SCI VET;2023

2. Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer;Cells;2023-03-17

3. Identification of protein candidates in spermatozoa of water buffalo (Bubalus bubalis) bulls helps in predicting their fertility status;Frontiers in Cell and Developmental Biology;2023-02-20

4. Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins;Asian Journal of Andrology;2020

5. Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men;Antioxidants;2019-10-16