Distribution and Cellular Localization of Caldendrin Immunoreactivity in Adult Human Forebrain-Reference-Cited by-同舟云学术

Distribution and Cellular Localization of Caldendrin Immunoreactivity in Adult Human Forebrain

Published:2003-08 Issue:8 Volume:51 Page:1109-1112
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Bernstein Hans-Gert¹,Seidenbecher Constanze I.²,Smalla Karl-Heinz¹,Gundelfinger Eckart D.²,Bogerts Bernhard¹,Kreutz Michael R.²

Affiliation:

1. Department of Psychiatry, Otto-von-Guericke-University, Magdeburg, Germany

2. AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany

Abstract

We investigated by immunohistochemistry (IHC) the distribution of caldendrin, the founding member of a novel family of neuronal calcium-binding proteins closely related to calmodulin, in human forebrain. Caldendrin immunoreactivity was unevenly distributed, with prominent staining in the paleo- and neocortex, hippocampus, and hypothalamus. With the exception of the hypothalamus, labeling was restricted to the somatodendritic compartment of neurons. This distribution completely matches that reported in rat, indicating that the cellular function is most likely conserved among species. Therefore, one prerequisite for functional studies in rodent models aimed at elucidation of mechanisms with relevance for humans can be based on the present findings.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/002215540305100816

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