Proteomics and Mass Spectrometry for Cancer Biomarker Discovery-Reference-Cited by-同舟云学术

Proteomics and Mass Spectrometry for Cancer Biomarker Discovery

Published:2007-01 Issue: Volume:2 Page:117727190700200
ISSN:1177-2719
Container-title:Biomarker Insights
language:en
Short-container-title:Biomark�Insights

Author:

Lu Ming¹²,Faull Kym F.³,Whitelegge Julian P.³,He Jianbo¹²,Shen Dejun¹²,Saxton Romaine E.⁴,Chang Helena R.¹²⁴

Affiliation:

1. Gonda/UCLA Breast Cancer Research Laboratory, Los Angeles, California

2. Revlon/UCLA Breast Center, Department of Surgery/Oncology, David Geffen School of Medicine, Los Angeles, California

3. The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry & Biobehavioral and the Neuropsychiatric Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles

4. Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, Los Angeles, California.

Abstract

Proteomics is a rapidly advancing field not only in the field of biology but also in translational cancer research. In recent years, mass spectrometry and associated technologies have been explored to identify proteins or a set of proteins specific to a given disease, for the purpose of disease detection and diagnosis. Such biomarkers are being investigated in samples including cells, tissues, serum/plasma, and other types of body fluids. When sufficiently refined, proteomic technologies may pave the way for early detection of cancer or individualized therapy for cancer. Mass spectrometry approaches coupled with bioinformatic tools are being developed for biomarker discovery and validation. Understanding basic concepts and application of such technology by investigators in the field may accelerate the clinical application of protein biomarkers in disease management.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Pharmacology,Molecular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/117727190700200005

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