Depicting the Implication of miR-378a in Cancers-Reference-Cited by-同舟云学术

Depicting the Implication of miR-378a in Cancers

Published:2022-01 Issue: Volume:21 Page:153303382211343
ISSN:1533-0346
Container-title:Technology in Cancer Research & Treatment
language:en
Short-container-title:Technol Cancer Res Treat

Author:

Qin Yuelan¹,Liang Renba²^ORCID,Lu Pingan³,Lai Lin¹,Zhu Xiaodong¹⁴⁵^ORCID

Affiliation:

1. Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China

2. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China

3. Faculty of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

4. Affiliated Wuming Hospital of Guangxi Medical University, Nanning, People's Republic of China

5. Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Guangxi Medical University, Ministry of Education, Nanning, People's Republic of China

Abstract

MicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, including proliferation, apoptosis, tumorigenesis, cancer invasion, metastasis, and therapeutic resistance. Interestingly, miR-378a has a dual functional role in either promoting or inhibiting tumorigenesis, independent of the cancer type. In this review, we comprehensively summarized the role and regulatory mechanisms of miR-378a in cancer development, hoping to provide a direction for its potential use in cancer therapy.

Funder

The Independent Project of Key Laboratory of Early Prevention and Treatment for Regional High-Incidence Tumor

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/15330338221134385

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