Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy

Author:

Tan Mingdian1ORCID,Ge Yizhi2,Wang Xiaogang3,Wang Yan45,Liu Yi1,He Feng5,Teng Hongqi6

Affiliation:

1. School of Medicine, Asian Liver Center, Stanford, CA, USA

2. The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital) and Jiangsu Institute of Cancer Research, Nanjing, China

3. The Third Affiliated Hospital of Soochow University, Changzhou, China

4. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA

5. Stanford University School of Medicine, Stanford, CA, USA

6. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract

In recent years, extracellular vesicles (EVs) have gained significant attention due to their tremendous potential for clinical applications. EVs play a crucial role in various aspects, including tumorigenesis, drug resistance, immune escape, and reconstruction of the tumor microenvironment. Despite the growing interest in EVs, many questions still need to be addressed before they can be practically applied in clinical settings. This paper aims to review EVs’ isolation methods, structure research, the roles of EVs in tumorigenesis and their mechanisms in multiple types of tumors, their potential application in drug delivery, and the expectations for their future in clinical research.

Funder

Postdoctoral Fund of People's Government of Jiangsu Province, China

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

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