Advances in Treatment Models of Advanced Gastric Cancer

Author:

Li Tao1,He Yufang2,Zhong Qinglei2,Yu Jiang1,Chen Xinhua1ORCID

Affiliation:

1. Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

2. The First Clinical Medical School, Southern Medical University, Guangzhou, Guangdong, China

Abstract

The prognosis of advanced gastric cancer (AGC) is extremely poor, and the therapeutic effect of traditional palliative chemotherapy is far from satisfactory. To overcome this bottleneck, palliative surgery resection, perioperative chemotherapy combined with surgical resection, hyperthermic intraperitoneal chemotherapy (HIPEC), pressurized intraperitoneal aerosol chemotherapy (PIPAC), radiation therapy, molecular-targeted therapy have been explored in AGC. Although considerable progress has been achieved, there is still no overwhelming therapeutic method. Due to the high heterogeneity of AGC, it is particularly vital to reshaped the paradigm of gastric cancer therapy according to the characteristics of clinical classifications and molecular subtypes.

Funder

"Climbing Program", Special Fund of Guangdong Province

College Students’ Innovative Entrepreneurial Training Plan Program of Southern Medical University, Guangzhou

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

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