Management of a Young Patient With High-risk Multiple Myeloma Complicated by Acquired von Willebrand Syndrome: A Diagnostic and Therapeutic Emergency

Author:

Ouadii Abakarim1ORCID,Pauline Condom23,Sophie Voisin2,Antoine Huart4,Aurore Perrot5,Teresa Botin6

Affiliation:

1. Oncohematology Department, Castres-Mazamet Hospital, Faculty of Health, Paul-Sabatier University, Toulouse, France

2. Hematology Laboratory, Rangueil Hospital, Toulouse University Hospital, Toulouse, France

3. Medical biology Laboratory, Castres-Mazamet Hospital, Toulouse, France

4. Nephrology Department, Rangueil Hospital, Toulouse University Hospital, Toulouse, France

5. Hematology Department, Cancer University Institute of Toulouse Oncopole, Toulouse University Hospital, Toulouse, France

6. Oncohematology Department, Castres-Mazamet Hospital, Toulouse, France

Abstract

Multiple myeloma associated with bleeding events secondary to von Willebrand syndrome is underdiagnosed. The management of this entity is highly complex, and aims to control the hemorrhagic syndrome and reduce plasma viscosity with plasmapheresis and multiple myeloma-specific treatment. The authors report the rare case of a young patient with high-risk multiple myeloma complicated by hyperviscosity syndrome and presenting an acquired von Willebrand syndrome with hemorrhagic manifestations, requiring urgent therapeutic management to save the patient's life.

Publisher

SAGE Publications

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