NH4I-mediated sp3 C-H cross-dehydrogenative coupling of benzylamines with 2-methylquinoline for the synthesis of E-2-styrylquinolines-Reference-Cited by-同舟云学术

NH4I-mediated sp3 C-H cross-dehydrogenative coupling of benzylamines with 2-methylquinoline for the synthesis of E-2-styrylquinolines

Published:2021-07-13 Issue:9-10 Volume:45 Page:903-910
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Li Xue¹^ORCID,Huang Bin¹,Wang JiangWei²,Zhang YuanYuan¹,Liao WeiBo¹

Affiliation:

1. Drug Research Center, Traditional Chinese Medicine Institute of Jiangxi, Nanchang, P.R. China

2. Jiangxi Provincial Hospital of Traditional Chinese medicine, Nanchang, P.R. China

Abstract

Without any metal catalyst, a simple and efficient method for the synthesis of E-2-styrylquinolines through sp3 C-H cross-dehydrogenative coupling of benzylamines with 2-methylquinolines mediated by NH4I under air is successfully developed. The oxidative olefination proceeded through deamination and sp3 C–H bond activation. A plausible mechanism is proposed for the construction of E-2-styrylquinolines.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/17475198211019253

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