Affiliation:
1. Department of Chemistry, Advanced Research Center for Science and Engineering, and Materials Research Laboratory for Bioscience and Photonics, Waseda University, Shinjuku-ku, Tokyo 169-8555, Japan
Abstract
A new short synthesis of 7,9-dialkylcyclohepta[ b]pyrimido[5,4- d]pyrrole-8(7 H),10(9 H)-dione derivatives consists of the reaction of 6-amino-1,3-dialkyluracils with tropone, 2-halotropones and 2,6-dibromotropone in an enamine-alkylation process, subsequent condensation of the amino group with carbonyl function, and aromatization under the reaction conditions.