Heterometallic coordination polymers: Treatment activity on diabetic foot by reducing the excess inflammatory response in the plantar tissue

Abstract

Two new heterometallic coordination polymers formulated as {[LaCo(2.5-pydc)2(H2O)4]Cl·4H2O}n (1, 2,5-H2pydc = pyridine-2,5-dicarboxylic acid) and {[LaCo2Cl3(4,4′-bpdc)2(H2O)3]·H2O}n (2, 4,4′-H2bpdc = 2,2′-bipyridyl-4,4′-dicarboxylic acid) have been solvothermally synthesized using the coordination between rare earth/transition metal ions and pyridinedicarboxylic acids. To develop new candidates for enhancing the therapeutic effect of improved negative pressure suction for diabetic foot, the activities of compounds 1 and 2 were studied. First, the ELISA (enzyme linked immunosorbent assay) detection kit was used and the inflammatory cytokines in the plantar tissue were measured. Besides, the TLR-4-NF-κB signaling pathway was measured with real-time reverse transcription-polymerase chain reaction.