Synthesis, characterization, and antimicrobial activities of novel double-armed benzo-15-crown-5 and their sodium and potassium complexes

Author:

Şener Cemaloğlu Öznur12,Ogutcu Hatice3,Hayvalı Zeliha1ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Ankara University, Ankara, Turkey

2. Department of Chemistry, Faculty of Science, Akdeniz University, Antalya, Turkey

3. Department of Field Crops, Faculty of Agriculture, Ahi Evran University, Kırşehir, Turkey

Abstract

New aldehyde- and halogen- (Cl, Br, I) substituted double-armed benzo-15-crown-5 derivatives are synthesized by the reactions of 4′,5′-bis(bromomethyl)benzo-15-crown-5 with 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, or 5-iodosalicylaldehyde. The sodium and potassium complexes are obtained by reaction of crown ether with sodium perchlorate and potassium iodide, respectively. Novel Schiff base compounds containing three groups of benzo-15-crown-5 are obtained from the condensation of aldehydes with 4′-aminobenzo-15-crown-5. The structures of all compounds are elucidated by elemental analysis, 1H, 13C NMR, IR, and mass spectra. The antifungal and antibacterial effects of the synthesized ligands are evaluated against pathogenic microorganisms and show varying degrees of inhibitory effects against the growth of different pathogenic strains. Graphical abstract

Funder

Scientific and Technical Research Council of Turkey

ankara universitesi

Publisher

SAGE Publications

Subject

General Chemistry

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