Synthesis, crystal structure, the Hirshfeld surface analysis, and antimicrobial activity of a three-dimensional Cu(II) complex with N-substituted biguanide

Author:

Shi Fei-Fei1ORCID,Xu Qian1,Wang Jing1,Zheng Yi1

Affiliation:

1. Department of Pharmacy, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, P.R. China

Abstract

A new antibacterial complex C4H15CuN5O7S, which is derived from the non-insulin-dependent diabetes mellitus drug metformin hydrochloride (MH) and cupric sulfate pentahydrate, is prepared and characterized. The complex shows that a three-dimensional supramolecular structure and the intermolecular interactions are analyzed by the Hirshfeld surface analysis. More importantly, compared with the MH free ligand, the present complex shows excellent antimicrobial activity, especially for Gram-negative bacteria.

Funder

Scientific Research Foundation of Graduate School of Jiangsu Agri-animal Husbandry Vocational College, China

natural science research of jiangsu higher education institutions of china

Publisher

SAGE Publications

Subject

General Chemistry

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