An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines-Reference-Cited by-同舟云学术

An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines

Published:2020-12-09 Issue:3-4 Volume:45 Page:326-333
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Ganesan Suresh¹,Sarangapani Muniraj¹^ORCID,Doble Mukesh²

Affiliation:

1. Department of Chemistry, Ramakrishna Mission Vivekananda College, Chennai, India

2. Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India

Abstract

An efficient approach for the synthesis of pyrazoline/pyrazole-tethered pyridinyl methanones is described via a one-pot, stepwise, sequential methodology using chalcones and pyridine-4-carbohydrazide as substrates through a Michael addition followed by cyclization. The reaction proceeds via a catalyst-, solvent-, work-up-, and column-chromatography-free method under melt conditions to provide the pyrazolines in short reaction times with high atom efficiency.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/1747519820977165

Reference23 articles.

1. Solvent-Free Synthesis of Chalcones

2. Solid-State Melt Reaction for the Domino Process: Highly Efficient Synthesis of Fused Tetracyclic Chromenopyran Pyrimidinediones Using Baylis−Hillman Derivatives

3. A multicomponent cascade reaction for the synthesis of novel chromenopyranpyrazole scaffolds

4. Chalcone: A Privileged Structure in Medicinal Chemistry

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Green and efficient three-component synthesis of novel isoniazid pyrazoles, molecular docking, antioxidant and antitubercular evaluation;Synthetic Communications;2023-07-14

2. PEG-mediated synthesis, antibacterial, antifungal and antioxidant studies of some new 1,3,5-trisubstituted 2-pyrazolines;Molecular Diversity;2022-11-11

3. Recent developments in one-pot stepwise synthesis (OPSS) of small molecules;iScience;2022-09

4. Synthesis of Trifluoromethylated Pyrazolidines, Pyrazolines and Pyrazoles via Divergent Reaction of β-CF3-1,3-Enynes with Hydrazines;Organic Letters;2021-09-20