Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent

Author:

Ma Zhanwei1,Zhou Min1,Ma Lin1,Zhang Min1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning, P.R. China

Abstract

Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.

Publisher

SAGE Publications

Subject

General Chemistry

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