Affiliation:
1. The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine / Research Center of Neurobiology, Shanxi University of Chinese Medicine, Jinzhong, P.R. China
2. School of Pharmacy, Shanxi Medical University, Jinzhong, P.R. China
3. College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, P.R. China
Abstract
Allyl alcohol and water can form the lowest boiling point azeotrope, but it is very hard to acquire high-purity allyl alcohol by normal distillation methods. Herein, a separation and purification protocol is developed for perfectly separating an azeotropic mixture of allyl alcohol and water using the salting-out method, in which three potassium phosphate salts, K5P3O10, K3PO4, and K4P2O7, are systematically investigated as salting-out agents, and finally a product consisting of > 99% allyl alcohol is obtained. A thermodynamic study demonstrates that this process involves endothermy and increment entropy. There is a good correlation between the solubility of allyl alcohol and the molar concentration of salt (mol per 1 kg water), and the solubility of the allyl alcohol in the organic phase or the water phase can be forecast using the mass percentage of salts. This work provides a new methodology for the efficient separation of an azeotropic mixture of allyl alcohol and water.
Funder
Leading Team of Medical Science and Technology, Shanxi Province
National Natural Science Foundation of China
Shanxi Provincial Department of Education Fund Project
Construction of a Chinese Medicine Discipline at Shanxi University of Chinese Medicine
Doctoral Research Initiation Fund of Shanxi University of Chinese Medicine
Shanxi Provincial Science and Technology Department Fund Project
the Shanxi Provincial Science and Technology Innovation Talent Team
Scientific and Technological Innovation Team of Shanxi University of Chinese Medicine