Affiliation:
1. Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Taizhou, P.R. China
2. ImmuOn Therapeutics, Nantong, P.R. China
Abstract
A series of 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3- b][1,2,4,5] tetrazine derivatives is synthesized and evaluated for their antitumor activities. These compounds exhibit potent antiproliferative activities against A549, Bewo, and MCF-7 cells. Molecular docking is performed to study the inhibitor–c-Met kinase interactions, and the results show that 6-ethoxyl-3-phenylethyl-[1,2,4]triazolo[4,3- b][1,2,4,5] tetrazine is potently bound to c-Met kinase with two hydrogen bonds and one π–π interaction. Based on these preliminary results, it is thought that compound 6-ethoxyl-3-phenylethyl-[1,2,4]triazolo[4,3- b][1,2,4,5] tetrazine with potent inhibitory activity may be a potential anticancer agent.
Funder
the Research Project of Taizhou Vocational and Technical College
the Zhejiang Public welfare Technology Research Project
This study was supported by the Science and Technology Innovation project of college students in Zhejiang
Cited by
6 articles.
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5. Triazines, tetrazines, and fused ring polyaza systems;Progress in Heterocyclic Chemistry;2021