Palladium-catalyzed Hiyama cross-couplings of pyrimidin-2-yl tosylates with organosilanes-Reference-Cited by-同舟云学术

Palladium-catalyzed Hiyama cross-couplings of pyrimidin-2-yl tosylates with organosilanes

Published:2022-01 Issue:1 Volume:46 Page:174751982110671
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Gong Hai-Peng¹^ORCID,Quan Zheng-Jun²,Wang Xi-Cun²

Affiliation:

1. College of Science, Gansu Agricultural University, Lanzhou, P.R. China

2. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, P.R. China

Abstract

An efficient palladium-catalyzed Hiyama reaction between various pyrimidin-2-yl tosylates with organosilanes has been developed. The use of CuCl with TBAF as additive is essential for promotion of the construction of the carbon–carbon bond. This procedure shows wide functional group tolerance for electrophilic pyrimidin-2-yl tosylates and has been extended to aromatic amino-substituted pyrimidin-2-yl tosylates, affording the desired C2-aryl and alkenyl pyrimidine derivatives in good to excellent yields.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/17475198211067163

Reference38 articles.

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