Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents

Published:2020-03-17 Issue:9-10 Volume:44 Page:536-542
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Li Wen¹,Chen Shu-Yi¹,Hu Wei-Nan¹,Zhu Mei¹,Liu Jia-Min¹,Fu Yi-Hong¹,Wang Zhen-Chao¹²^ORCID,OuYang Gui-Ping¹²³

Affiliation:

1. College of Pharmacy, Guizhou University, Guiyang, P.R. China

2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, P.R. China

3. Drug Synthetic Engineering Laboratory of Guizhou Province, Guiyang, P.R. China

Abstract

A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/1747519820910384

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