The functional and molecular roles of p75 neurotrophin receptor (p75<sup>NTR</sup>) in epilepsy-Reference-Cited by-同舟云学术

The functional and molecular roles of p75 neurotrophin receptor (p75^NTR) in epilepsy

Published:2024-04-22 Issue: Volume:16 Page:
ISSN:1179-5735
Container-title:Journal of Central Nervous System Disease
language:en
Short-container-title:J Cent Nerv Syst Dis

Author:

Turkistani Areej¹,Al-kuraishy Hayder M.²,Al-Gareeb Ali I.²,Albuhadily Ali K.²,Elhussieny Omnya³,AL-Farga Ammar⁴,Aqlan Faisal⁵,Saad Hebatallah M.⁶^ORCID,Batiha Gaber El-Saber⁷

Affiliation:

1. Department of pharmacology and toxicology, Collage of Medicine, Taif University, Taif, Kingdom of Saudi

2. Professor in department of clinical pharmacology and medicine, college of medicine, Mustansiriyah University, Baghdad, Iraq

3. Department of Histology and Cytology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, Egypt

4. Biochemistry Department, College of Sciences, University of Jeddah, Jeddah, Saudia Arbia

5. Department of Chemistry, College of Sciences, Ibb University, Ibb Governorate, Yemen

6. Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt

7. Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt

Abstract

Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75NTR expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE). Over-expression of p75NTR is linked with the pathogenesis of epilepsy, and augmentation of pro-BDNF/p75NTR is implicated in the pathogenesis of epilepsy. However, the precise mechanistic function of p75NTR in epilepsy has not been completely elucidated. Therefore, this review aimed to revise the mechanistic pathway of p75NTR in epilepsy.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/11795735241247810

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