Lymphomatoid papulosis in a patient treated with glatiramer acetate and the glatiramoid Glatopa for multiple sclerosis: A case report-Reference-Cited by-同舟云学术

Lymphomatoid papulosis in a patient treated with glatiramer acetate and the glatiramoid Glatopa for multiple sclerosis: A case report

Published:2021-01 Issue: Volume:13 Page:117957352110537
ISSN:1179-5735
Container-title:Journal of Central Nervous System Disease
language:en
Short-container-title:J Cent Nerv Syst Dis

Author:

Shirani Afsaneh¹^ORCID,Dalton Scott R²,Avery Eric J³^ORCID,Arcot Jayagopal Lakshman¹,Meyer Christina⁴,Stuve Olaf⁵^ORCID,Zabad Rana¹

Affiliation:

1. Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

2. Sagis Dermatopathology, Houston, TX, USA

3. Nebraska Hematology Oncology, Lincoln, NE, USA

4. Dermatology Associates of Lincoln, Lincoln, NE, USA

5. Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX; VA North Texas Health Care System, Dallas VA Medical Center, Dallas, TX, USA

Abstract

A 48-year-old Caucasian woman with history of multiple sclerosis (MS) presented with erythematous papulonodular lesions in her extremities and trunk. She was being treated with glatiramer acetate (GA) for the past 10 years and the glatiramoid, Glatopa, for 2 years prior to this presentation. A skin biopsy showed CD30+ lymphoproliferative disorder consistent with lymphomatoid papulosis (LyP). Three weeks after stopping Glatopa, her skin lesions were improved. It remains unclear whether GA’s or Glatopa’s capability to alter T-cell differentiation, may have a link with LyP. This case report is a reminder to be vigilant for skin lesions in patients with MS.

Publisher

SAGE Publications

Subject

Management Science and Operations Research,Mechanical Engineering,Energy Engineering and Power Technology

Link

http://journals.sagepub.com/doi/pdf/10.1177/11795735211053784

Reference10 articles.

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3. The Evolving Mechanisms of Action of Glatiramer Acetate

4. CD30 Antigen and Multiple Sclerosis: CD30, an Important Costimulatory Molecule and Marker of a Regulatory Subpopulation of Dendritic Cells, Is Involved in the Maintenance of the Physiological Balance between TH1/TH2 Immune Responses and Tolerance

5. Cutaneous adverse events associated with disease-modifying treatment in multiple sclerosis: a systematic review

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