A rare case report of gemcitabine-induced thrombotic microangiopathies

Author:

Madkhali Mohammed Ali1ORCID

Affiliation:

1. Division of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Hannover Medical School, Hannover, Germany

Abstract

A 65-year-old female patient with breast cancer and soft tissue sarcoma who experienced a gemcitabine-induced thrombotic microangiopathies manifestation visited the emergency department. The renal biopsy revealed endothelial cell swelling, focal reduplication of glomerular basement membrane, and narrowed capillary lumens with fibrin deposition and fragmented erythrocytes which are compatible with thrombotic microangiopathies. The patient was presented with organ injury, acute renal failure with the need for hemodialysis technique. The patient recovered after the appropriate treatment. Continuous observation of renal function during gemcitabine treatment regularly and withdrawal of treatment if acute kidney injury occurs is essential as acute kidney injury along with thrombotic microangiopathies may prove to be life-threatening.

Publisher

SAGE Publications

Subject

General Medicine

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1. Multiple drugs;Reactions Weekly;2021-06

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