Progressive use of nanocomposite hydrogels materials for regeneration of damaged cartilage and their tribological mechanical properties

Abstract

Osteoarthritis (OA) is a non-inflammatory deteriorating debilitating state that bring about remarkable health and economic issues globally. Break down/deterioration of the articular cartilage (AC) is one of the pathologic characteristics of osteoarthritis (OA). Nanocomposite hydrogels (NCH) materials are evolving as a potential class of scaffolds for organ regeneration and tissue engineering. In recent years, innovative hydrogels specifically loaded with nanoparticles have been developed and synthesized with the goal of changing conventional cartilage treatments. The detailed development of a tailored nanocomposite hydrogels (NCH) material utilized for tissue engineering is presented in this review study. Also, the mechanical characteristics, particularly the tribological behavior, of these produced NCH have been highlighted. Large amounts of research and data on the hydrogel substance utilized in cartilage healing are summarized in the current review study. When determining future research gaps in the area of hydrogels for cartilage regeneration, such information will provide researchers an advantage to further develop NCH.