Anti-N-methyl-D-aspartate encephalitis – a case study of symptomatic progression

Author:

Bowes Emma1,Levy Florence2,Lawson John3,Mandalis Anna4,Mohan Adith5,Shannon Weickert Cynthia6

Affiliation:

1. Psychiatry Registrar, Prince of Wales Hospital, Sydney, NSW, and; St George Hospitals, Australia

2. Conjoint Professor, School of Psychiatry, University of New South Wales, Sydney, NSW, and; and Senior Staff Specialist, Prince of Wales Hospital, Randwick, NSW, Australia

3. Department of Neurology, Sydney Children’s Hospital and Conjoint Senior Lecture, School of Women and Childrens Health, University of New South Wales, Sydney, NSW, Australia

4. Clinical Neuropsychologist, Department of Psychology, Sydney Children’s Hospital, Sydney, NSW, Australia

5. Staff Specialist Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia

6. Neuroscience Research Australia; Professor, School of Psychiatry, University of New South Wales, Australia; Schizophrenia Research Institute, Sydney, NSW, Australia

Abstract

Objective: To present the diagnosis course and sequelae of a case of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, drawing attention to early psychiatric symptoms. Method: The literature on anti-NMDA encephalitis is reviewed and possible psychopathological mechanisms discussed. Result: New onset psychoses, presenting with the combination of hallucinations, dyskinesias and seizures and progressing to catatonia should be referred to neurology for consideration of anti-NMDA receptor encephalitis. Conclusion: Early diagnosis is important for a favourable prognosis.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

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