Clozapine-related tachycardia: A conundrum to identify and treat-Reference-Cited by-同舟云学术

Clozapine-related tachycardia: A conundrum to identify and treat

Published:2024-01-02 Issue:1 Volume:32 Page:84-88
ISSN:1039-8562
Container-title:Australasian Psychiatry
language:en
Short-container-title:Australas Psychiatry

Author:

Brennan Dermot¹,Lal Sweta¹²,Hugo Frans¹,Waters Flavie³⁴⁵^ORCID,Shymko Gordon²⁴

Affiliation:

1. Armadale Health Service, East Metropolitan Health Service, Armadale, WA, Australia

2. Peel and Rockingham Kwinana (PaRK) Mental Health Service, South Metropolitan Health Service, Rockingham, WA, Australia

3. School of Psychological Sciences, The University of Western Australia, Perth, WA, Australia

4. Black Swan Health, Headspace Youth Early Psychosis Program, Perth, WA, Australia

5. North Metropolitan Health Service, Clinical Research Centre, Mount Claremont, WA, Australia

Abstract

Objective This study examined the rates and persistence of clozapine-induced tachycardia and heart-rate differences in patients treated with β-blockers in the largest sample of patients with a psychotic disorder to date. Method An audit of medical files for 101 patients who attended a clozapine community clinic and analysis of monthly measurements of resting heart rates. Results 51% met the clinical criteria for tachycardia. Heart rates were stable over time. β-blockers were associated with small but significant reductions in heart rates. Conclusion The cardiovascular risks of clozapine are often overlooked. β-blockers are useful in lowering heart rates but they may be insufficient to reduce cardiac risk.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/10398562231224156

Reference29 articles.

1. Update on the Clinical Efficacy and Side Effects of Clozapine

2. Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections

3. Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality