Impact of long-acting buprenorphine injection on methamphetamine use: A retrospective cohort study

Abstract

Objective The aim is to assess the impact of long-acting buprenorphine (LAI-BNP) on frequency of methamphetamine (MA) use. Methods We undertook an observational, descriptive, retrospective cohort study of patients of a public, tertiary, community-based Alcohol and Other Drug Service (AODS) with opioid use disorder (OUD) treated with LAI-BNP who are current or past users of MA. We assessed the changes of frequency of use in their MA use at start (baseline), 3 and 6 months of LAI-BNP. Results Study included 59 participants. Based on their MA use at the commencement of LAI-BNP, the sample was further sub-grouped as active users ( n = 30) and past users ( n = 29). At 6 months of LAI-BNP, all the past users remained abstinent from MA use. 70% ( n = 21) of participants with active MA use had reduced or ceased their MA use while 17% ( n = 5) increased their MA use at 6 months. Conclusions The results favour the use of LAI-BNP as a potential treatment for MA use.