Do benzodiazepines reduce the efficacy of transcranial magnetic stimulation?-Reference-Cited by-同舟云学术

Do benzodiazepines reduce the efficacy of transcranial magnetic stimulation?

Published:2024-02-01 Issue:3 Volume:32 Page:180-185
ISSN:1039-8562
Container-title:Australasian Psychiatry
language:en
Short-container-title:Australas Psychiatry

Author:

Tran Lana¹,Hahn Lisa²,Gill Shane³,Ng Felicity⁴,Clarke Patrick⁴,Paterson Tom⁴,Galletly Cherrie⁵^ORCID

Affiliation:

1. Psychiatry Trainee, School of Medicine, Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia

2. Research Officer, Ramsay Clinic Adelaide, Ramsay Health Care (SA) Mental Health Services, Adelaide, SA, Australia

3. Consultant Psychiatrist, Ramsay Clinic Adelaide, Ramsay Health Care (SA) Mental Health Services, Adelaide, SA, Australia; Director of Psychiatry Training, Adelaide, SA, Australia; and School of Medicine, Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia

4. Consultant Psychiatrist, School of Medicine, Discipline of Psychiatry, University of Adelaide; and Ramsay Clinic Adelaide, Ramsay Health Care (SA) Mental Health Services, Adelaide, SA, Australia

5. Emerita Professor, School of Medicine, Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia; and Consultant Psychiatrist, Northern Adelaide Local Health Network, Adelaide, SA, Australia

Abstract

Objective To investigate the effect of concomitant use of benzodiazepines on the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant major depressive disorder (TR-MDD). Methods This is a retrospective study comparing rTMS treatment outcomes between patients taking benzodiazepines ( n = 59) and those who were not ( n = 136). Participants completed the HAM-A, HAM-D17, MADRS and ZUNG at baseline and at the end of treatment. Results Patients taking benzodiazepines during rTMS treatment did not show any difference in partial response, response or remission rates compared to patients not treated with benzodiazepines. There was a significant decrease ( p < .0001) in depression and anxiety scores from baseline to post-treatment among both groups. Conclusions Concomitant benzodiazepine treatment had no effect on the efficacy of rTMS treatment of TRD, contrary to previous research.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/10398562241229623

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