Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease

Author:

Loi Samantha M1ORCID,Walterfang Mark2,Velakoulis Dennis2,Looi Jeffrey CL3ORCID

Affiliation:

1. Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Department of Psychiatry, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia

2. Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Melbourne Neuropsychiatry Centre, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia

3. Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Melbourne Neuropsychiatry Centre, University of Melbourne, Parkville, VIC, and; Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra Hospital, Canberra, ACT, Australia

Abstract

Objectives: This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington’s disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area. Conclusions: Neuropsychiatric symptoms may precede the classic motor clinical symptoms of HD (prodromal HD) by decades and cause significant functional impairment. Early recognition and comprehensive non-pharmacological, usually in combination with pharmacological, treatment is essential.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

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