Affiliation:
1. School of Medicine, Anhembi Morumbi University (UAM), Avenida Deputado Benedito Matarazzo, 6707 - Jardim Aquarius, São José dos Campos 12242-010, SP, Brazil
2. Post-graduation Program in Biomedical Engineering, Federal University of Sao Paulo (UNIFESP), Rua Talim, 330 - Vila Nair, São José dos Campos 12231-280, SP, Brazil
Abstract
This review presents information from several studies that have demonstrated the antiviral activity of extracts ( Andrographis paniculata, Artemisia annua, Artemisia afra, Cannabis sativa, Curcuma longa, Echinacea purpurea, Olea europaea, Piper nigrum, and Punica granatum) and phytocompounds derived from medicinal plants (artemisinins, glycyrrhizin, and phenolic compounds) against SARS-CoV-2. A brief background of the plant products studied, the methodology used to evaluate the antiviral activity, the main findings from the research, and the possible mechanisms of action are presented. These plant products have been shown to impede the adsorption of SARS-CoV-2 to the host cell, and prevent multiplication of the virus post its entry into the host cell. In addition to antiviral activity, the plant products have also been demonstrated to exert an immunomodulatory effect by controlling the excessive release of cytokines, which is commonly associated with SARS-CoV-2 infections.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
14 articles.
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