Author:
Iravani Omid,Tay Benjamin Wei-Rong,Chua Pei-Jou,Yip George Wai-Cheong,Bay Boon-Huat
Abstract
Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight junctions. It is now established that CLDNs are differentially altered in gastric cancer and CLDN proteins are believed to play different roles in the growth and progression of gastric cancer.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
23 articles.
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