Quantitative Trait Loci Influencing Hepatic Copper in Rats-Reference-Cited by-同舟云学术

Quantitative Trait Loci Influencing Hepatic Copper in Rats

Published:2002-07 Issue:7 Volume:227 Page:529-534
ISSN:1535-3702
Container-title:Experimental Biology and Medicine
language:en
Short-container-title:Exp Biol Med (Maywood)

Author:

de Wolf I.D.¹,Bonné A.C.M.¹,Fielmich-Bouman X.M.¹,Oost B.A. van²³⁴,Beynen A.C.¹⁵,Zutphen L.F.M. van¹,Lith H.A. van¹

Affiliation:

1. Department of Laboratory Animal Science

2. Department of Clinical Sciences of Companion Animals

3. Department of Equine Sciences

4. Department of Farm Animal Health

5. Department of Nutrition, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, P.O. Box 80.166, NL-3508 TD Utrecht, The Netherlands

Abstract

Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd × BC/CpbU) F2-intercross was genetically analyzed. From each F2 animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0–15.5% of the genetic variance of liver copper content.

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://journals.sagepub.com/doi/pdf/10.1177/153537020222700718

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