Active bone material containing modified recombinant human bone morphogenetic protein-2 induces bone regeneration in rabbit spina bifida

Author:

Sun Xue-Cheng12,Wang Hu13ORCID,Li Jian-Hui1,Yin Li-Qiang4,Yan Yu-Fang4,Ma Xu13,Xia Hong-Fei13

Affiliation:

1. Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health Engineering Technology Research (NRIFP), National Research Institute for Family Planning, Beijing 100081, China

2. Medical Genetics, Zibo Maternal and Child Health Hospital, Zibo 255000, China

3. Graduate Schools, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China

4. Yantai Zhenghai Bio-Tech Co., Ltd., Yantai 264006, China

Abstract

This study focuses on spina bifida, which is a high incidence among the current clinical manifestations of human birth defects. Because in the treatment of bone defects, the source of autologous bone is limited and it is easy to cause secondary injury to the patient. At the same time, since the bone tissue in animals needs to perform a variety of biological functions, its complex structure cannot be replaced by a single material. Therefore, in this study, we used Japanese white rabbits to establish an animal model similar to human congenital spina bifida. The established animal model is used to screen the best regenerative repair products for the treatment of congenital spondylolisthesis defects, and to evaluate the safety of regenerative repair products. The results show that bone morphogenetic protein (BMP)-2 combined with collagen material has a better regeneration effect than collagen material alone, and it did not negatively affect the health of animals. This study is not only suitable for the screening of large-scale biomaterials, accelerating the research progress of regenerative repair products, but also conducive to the research on the mechanism of regeneration and repair of various materials.

Funder

National Key Research and Development Program of China

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

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