Metallothionein as a Prognostic Biomarker in Breast Cancer

Author:

Bay Boon-Huat1,Jin Rongxian2,Huang Jingxiang1,Tan Puay-Hoon13

Affiliation:

1. Department of Anatomy, National University of Singapore, Singapore 117 597

2. Department of Radiation Oncology and Department of Pathology, Wayne State University, Detroit, Michigan 48202

3. Department of Pathology, Singapore General Hospital, Singapore 169608

Abstract

Breast cancer is the most common cancer in women, with a general upward trend in incidence. Basic and clinical breast cancer research has continued at a rapid pace, in the endeavor to understand the biology of the disease so as to improve management of patients. Besides traditional pathological indicators, expression of molecular markers in breast cancer has also been comprehensively investigated. This paper will focus on the prognostic utility of metallothioneins (MTs), a family of low molecular weight metal binding proteins encoded by at least 10 functional MT genes that are associated with cell proliferation in breast cancer. Evidence that MT is a potential prognostic biomarker for breast cancer is supported by many reports in the literature. Expression of the MT protein has been detected by immunohistochemistry in a significant portion of invasive ductal breast cancers. MT expression has also been well studied in association with traditional clinico-pathological parameters of breast cancers. Generally, higher MT expression in breast cancers is predictive of worse patient outcomes. The relationship of MT isoforms to histological grade, estrogen receptor (ER) status, and prognosis will also be discussed.

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

Reference74 articles.

1. BreastedJH. The Edwin Smith Surgical Papyrus. Chicago: University of Chicago Press, pp403–406, 1990.

2. Cancer incidence and mortality, 1973-1995

3. SeowA, KohWP, ChiaKS, LeeHP, ShanmugaratnamK. Cancer incidence in Singapore 1968–2002. Singapore: Singapore Cancer Registry Report No. 6, pp120–121, 2004.

4. Breast Cancer: Magnitude of the Problem and Descriptive Epidemiology

5. ParkinDM, WhelanSL FerlayJ, TeppoL, ThomasDB. Cancer Incidence in five continents. Lyon, France: International Agency for Research on Cancer (IARC) Press, IARC Scientific Publications, No. 155, Vol. VIII:pp603–605, 2003.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3