The reduced soluble fibrinogen-like protein 2 and regulatory T cells in acute coronary syndrome-Reference-Cited by-同舟云学术

The reduced soluble fibrinogen-like protein 2 and regulatory T cells in acute coronary syndrome

Published:2015-10-28 Issue:4 Volume:241 Page:421-425
ISSN:1535-3702
Container-title:Experimental Biology and Medicine
language:en
Short-container-title:Exp Biol Med (Maywood)

Author:

Liu Kun¹,Li Ting²,Huang Shiyuan²,Long Rui²,You Ya²,Liu Jinping³,Wang Zhaohui²

Affiliation:

1. Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 0086, China

2. Department of Geriatrics, Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 0086, China

3. Department of Cardiac Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 0086, China

Abstract

Soluble fibrinogen-like protein 2, sfgl2, is the new effector of CD4+CD25+FOXP3+ regulatory T cell (Treg) and exerts immunosuppressive activity. We design this study to investigate the possible role of sfgl2 in atherosclerosis. A total of 58 acute coronary syndrome (ACS) patients, together with 22 stable angina (SA) patients and 31 normal coronary artery (NCA) people were enrolled in our study. Serum level of sfgl2 and plasma level of Treg were respectively measured. In line with the change of Treg, serum level of sfgl2 in ACS (8.70 ng/mL) was significantly decreased ( P = 0.003), compared with that in SA (11.86 ng/mL) and NCA (17.55 ng/mL). Both sfgl2 and Treg level were obviously decreased in ACS; Sfgl2 may play a protective role in atherosclerosis.

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1535370215612138

Reference21 articles.

1. Heart Disease and Stroke Statistics—2015 Update

2. Inflammation as a Cardiovascular Risk Factor

3. Regulatory T Cells and Immune Tolerance

4. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection

5. The regulatory T cell effector soluble fibrinogen-like protein 2 induces tubular epithelial cell apoptosis in renal transplantation

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