Renal cystic disease in tuberous sclerosis complex-Reference-Cited by-同舟云学术

Renal cystic disease in tuberous sclerosis complex

Published:2021-09-06 Issue:19 Volume:246 Page:2111-2117
ISSN:1535-3702
Container-title:Experimental Biology and Medicine
language:en
Short-container-title:Exp Biol Med (Maywood)

Author:

Kumar Prashant¹²,Zadjali Fahad¹²³,Yao Ying¹²,Bissler John J¹²⁴^ORCID

Affiliation:

1. Department of Pediatrics, University of Tennessee Health Science Center and Le Bonheur Children’s Hospital, Memphis, TN 38105, USA

2. Children’s Foundation Research Institute (CFRI), Le Bonheur Children’s Hospital, Memphis, TN 38105, USA

3. Department of Clinical Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, PC 123, Oman

4. Pediatric Medicine Department, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA

Abstract

Tuberous sclerosis complex (TSC) is associated with TSC1 or TSC2 gene mutations resulting in hyperactivation of the mTORC1 pathway. This mTORC1 activation is associated with abnormal tissue development and proliferation such that in the kidney there are both solid tumors and cystic lesions. This review summarizes recent advances in tuberous sclerosis complex nephrology and focuses on the genetics and cell biology of tuberous sclerosis complex renal disease, highlighting a role of extracellular vesicles and the innate immune system in disease pathogenesis.

Funder

U.S. Department of Defense

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://journals.sagepub.com/doi/pdf/10.1177/15353702211038378

Reference73 articles.

1. RENAL LESION GROWTH IN CHILDREN WITH TUBEROUS SCLEROSIS COMPLEX

2. Renal Lesions in Tuberous Sclerosis

3. Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review

4. Causes of Death in Patients With Tuberous Sclerosis

5. Causes of mortality in individuals with tuberous sclerosis complex

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