Current evidence for vitamin D in intestinal function and disease

Author:

Hassanshahi Mohammadhossein1,Anderson Paul H1,Sylvester Cyan L1,Stringer Andrea M12ORCID

Affiliation:

1. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia

2. Adelaide Medical School, The University of Adelaide, Adelaide 5000, Australia

Abstract

Vitamin D activity is associated with the modulation of a wide variety of biological systems, in addition to its roles in calcium homeostatic mechanisms. While vitamin D is well known to promote gastrointestinal calcium absorption, vitamin D also plays a role in attenuating and/or preventing the progression of several gastrointestinal diseases including Crohn’s disease, ulcerative colitis, and colorectal cancer, and may also play a role in chemotherapy-induced intestinal mucositis. The pro-differentiation, immunomodulatory, and anti-inflammatory effects of vitamin D, which has been reported in numerous circumstances, are key potential mechanisms of action in the prevention of gastrointestinal disorders. While the debate of the effectiveness of vitamin D to treat bone pathologies continues, the clinical importance of vitamin D therapy to prevent gastrointestinal disorders should be investigated given current evidence, using both nutritional and pharmaceutical intervention approaches.Impact statementThe non-skeletal functions of vitamin D play an important role in health and disease. The anti-inflammatory properties and maintenance of intestinal function fulfilled by vitamin D impact other systems in the body though downstream processing. This review provides insight into the mechanisms underpinning the potential benefits of vitamin D in both maintaining intestinal homeostasis and associated diseased states.

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

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