Cannabidiol for musculoskeletal regenerative medicine

Author:

Marques Azzini Gabriel Ohana1,Marques Azzini Vitor Ohana1,Santos Gabriel Silva1,Visoni Silvia1,Fusco Maria Alice2,Beker Natascha Szumsztajn1,Mahmood Ansar3,Bizinotto Lana João Vitor14,Jeyaraman Madhan5678ORCID,Nallakumarasamy Arulkumar89,Jeyaraman Naveen810ORCID,da Fonseca Lucas Furtado111ORCID,Luz Arab Miguel Gustavo112,Vicente Rodrigo113,Rajendran Ramya Lakshmi14,Gangadaran Prakash1415ORCID,Ahn Byeong-Cheol1415ORCID,Duarte Lana José Fabio Santos1

Affiliation:

1. Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil

2. Hospital Naval Marcílio Dias, Rio de Janeiro 20725-090, Brazil

3. University Hospitals Birmingham, Birmingham B15 2PR, UK

4. Medical Specialties School Centre, Centro Universitário Max Planck, Indaiatuba, 13343-060, Brazil

5. Department of Orthopaedics, A.C.S. Medical College and Hospital, Dr.M.G.R. Educational and Research Institute, Chennai 600056, India

6. Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India

7. South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, USA

8. Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India

9. Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar 751019, India

10. Department of Orthopaedics, Atlas Hospitals, Tiruchirappalli 620002, India

11. Universidade Federal de São Paulo (UNIFESP), São Paulo, 04021-001, Brazil

12. Saúde Máxima (SAMAX), São Paulo, 01239-040, Brazil

13. Ultra Sports Science, São Paulo, Brazil

14. Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu 41944, Republic of Korea

15. BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea

Abstract

Chronic musculoskeletal (MSK) pain is one of the most prevalent causes, which lead patients to a physician’s office. The most common disorders affecting MSK structures are osteoarthritis, rheumatoid arthritis, back pain, and myofascial pain syndrome, which are all responsible for major pain and physical disability. Although there are many known management strategies currently in practice, phytotherapeutic compounds have recently begun to rise in the medical community, especially cannabidiol (CBD). This natural, non-intoxicating molecule derived from the cannabis plant has shown interesting results in many preclinical studies and some clinical settings. CBD plays vital roles in human health that go well beyond the classic immunomodulatory, anti-inflammatory, and antinociceptive properties. Recent studies demonstrated that CBD also improves cell proliferation and migration, especially in mesenchymal stem cells (MSCs). The foremost objective of this review article is to discuss the therapeutic potential of CBD in the context of MSK regenerative medicine. Numerous studies listed in the literature indicate that CBD possesses a significant capacity to modulate mammalian tissue to attenuate and reverse the notorious hallmarks of chronic musculoskeletal disorders (MSDs). The most of the research included in this review report common findings like immunomodulation and stimulation of cell activity associated with tissue regeneration, especially in human MSCs. CBD is considered safe and well tolerated as no serious adverse effects were reported. CBD promotes many positive effects which can manage detrimental alterations brought on by chronic MSDs. Since the application of CBD for MSK health is still undergoing expansion, additional randomized clinical trials are warranted to further clarify its efficacy and to understand its cellular mechanisms.

Funder

National Research Foundation of Korea

Publisher

Frontiers Media SA

Subject

General Biochemistry, Genetics and Molecular Biology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3