Treatment of Viral and Neoplastic Diseases with Double-Stranded RNA Derivatives and Other New Agents-Reference-Cited by-同舟云学术

Treatment of Viral and Neoplastic Diseases with Double-Stranded RNA Derivatives and Other New Agents

Published:2006-09 Issue:8 Volume:231 Page:1283-1286
ISSN:1535-3702
Container-title:Experimental Biology and Medicine
language:en
Short-container-title:Exp Biol Med (Maywood)

Author:

Ambrus Julian L.¹,Chadha Kailash C.²,Islam Anwarul¹,Akhter Selina¹,Ambrus Julian L.¹

Affiliation:

1. Department of Internal Medicine, State University of New York at Buffalo, Buffalo General Hospital/Kaleida Health System, Buffalo, New York 14203

2. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263

Abstract

Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyl: MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2′-deoxyoligocytidilates and telomerase inhibitors.

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://journals.sagepub.com/doi/pdf/10.1177/153537020623100801

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