Changing HIV Infection–Related Mortality Rate and Causes of Death Among Persons With HIV Infection Before and After the Introduction of Highly Active Antiretroviral Therapy

Abstract

Objectives: To compare the trends in death rates and the causes of deaths before and after the introduction of highly active antiretroviral therapy. Methods: This is a retrospective study based on chart review of all HIV-related deaths between January 1997 and December 2005. Results: The HIV-specific death rate declined from 34.12 per 100 000 adult population during 1997-1999 to 17.21 per 100 000 adult population during 2003-2005 when highly active anti-retroviral therapy was available. The proportion of all HIV-related deaths among persons newly diagnosed with HIV during the terminal hospitalization decreased from 93% during 1997-1999 to 28% during 2003-2005. Opportunistic infection was at least one of the causes of death in nearly half of all cases. Conclusions: Although, the HIV-specific death rates have declined significantly since the introduction of highly active antiretroviral therapy, HIV infection continues to contribute to the premature deaths among adults, mainly because of the late presentation.