Nonadherence Increases the Risk of Hospitalization Among HIV-Infected Antiretroviral Naïve Patients Started on HAART-Reference-Cited by-同舟云学术

Nonadherence Increases the Risk of Hospitalization Among HIV-Infected Antiretroviral Naïve Patients Started on HAART

Published:2008-09 Issue:5 Volume:7 Page:238-244
ISSN:1545-1097
Container-title:Journal of the International Association of Physicians in AIDS Care
language:en
Short-container-title:Journal of the International Association of Physicians in AIDS Care

Author:

Fielden Sarah J.¹,Rusch Melanie L. A.²,Yip Benita³,Wood Evan⁴,Shannon Kate⁵,Levy Adrian R.⁶,Montaner Julio S. G.⁴,Hogg Robert S.⁷

Affiliation:

1. B.C. Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Department of Interdisciplinary Studies, University of British Columbia, Vancouver, British Columbia, Canada

2. Division of International Health & Cross-Cultural Medicine, University of California, San Diego, California,

3. B.C. Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

4. B.C. Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

5. B.C. Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada

6. Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada

7. Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada, B.C. Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

Abstract

Background. Since the advent of highly active antiretroviral therapy (HAART), AIDS-related hospitalizations have decreased. The objective of this study was to assess the impact of adherence on hospitalization among antiretroviral-naïve HIV-infected persons initiating HAART. Methods. Analysis was based on a cohort of individuals initiating HAART between 1996 and 2001. The primary outcome was hospitalization for one or more days. Survival methods were used to assess the impact of adherence on hospitalization. Results. Of 1605 eligible participants, 672 (42%) were hospitalized for one or more days after initiating HAART. Median adherence levels were 92 (IQR: 58, 100) and 100 (IQR: 83, 100) among those ever and never hospitalized, respectively. After controlling for confounders, those with <95% adherence had 1.88 times (95% CI: 1.60, 2.21) higher risk for hospitalization. Conclusions. Suboptimal adherence among HIV-infected patients taking HAART predicts hospitalization. Identifying and addressing factors contributing to poor adherence early in treatment could improve patient care and lower hospitalization costs.

Publisher

SAGE Publications

Subject

Infectious Diseases,Dermatology,Immunology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1545109708323132

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2. Mortality in the Highly Active Antiretroviral Therapy Era

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