Biomarker Validation: Context and Complexities

Author:

McShane Lisa M.

Abstract

Validation of a biomarker-based medical product development tool or clinical test is an evidentiary process that must be tailored to the proposed use. Appropriate data and analyses are needed to demonstrate that the biomarker meets analytical and clinical performance criteria consistent with favorable benefit: risk balance.

Publisher

Cambridge University Press (CUP)

Subject

Health Policy,General Medicine,Issues, ethics and legal aspects

Reference20 articles.

1. 2. Id.

2. 11. “Clinical Laboratory Improvement Amendments (CLIA),” Centers for Medicare & Medicaid Services (CMS), available at (last visited July 22, 2019).

3. 5. “Biomarkers Consortium — Workshop: Defining an Evidentiary Criteria Framework for Surrogate Endpoint Qualification,” Foundation for the National Institutes of Health, available at (last visited July 22, 2019).

4. Challenges and Opportunities for Biomarker Validation

5. Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)

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