Effects of Age, Density, and Geometry on the Bending Strength of Human Metatarsals

Abstract

In this basic study, we investigated the relative roles of donor age, bone density, and bone geometry in determining structural strength of human metatarsals tested in a four-point bending configuration. Density measurements were made noninvasively using dual energy x-ray absorptiometry, and geometric measurements were made by digitally imaging cross-sections of specimens. Correlations between area bone mineral density and metatarsal strength were strong (r2 = 0.83,0.81 for second and third metatarsals, respectively) and were not improved by including cross-sectional area or minimum moment of inertia in multiple regression analyses. Increased donor age was associated with decreased bending strength (r2 = 0.51 and 0.45, respectively), which was expected because increased age correlated significantly with decreased bone density (r2 = 0.69 and 0.80, respectively). These results indicate that the strength of human metatarsals generally decreases with age and that this decrease is likely attributable to decreased bone density. Moreover, the results indicate that noninvasive dual energy x-ray absorptiometry measurements of metatarsal density are useful for assessing metatarsal strength and that additional measurements of bone geometry are not required.