Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus

Author:

Rias Yohanes Andy123ORCID,Tsai Hsiu Ting34ORCID,Thato Ratsiri5ORCID,Apriyanto Bagus Sholeh1,Chou Kuei Ru3,Ho Shu Chuan67ORCID,Sun Chia Hsuan3

Affiliation:

1. Faculty of Health and Medicine, College of Nursing, Institut Ilmu Kesehatan Bhakti Wiyata, Kediri, Indonesia

2. Graduate School of Chulalongkorn University, Bangkok, Thailand

3. School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC

4. Post-Baccalaureate Program in Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC

5. Faculty of Nursing, Chulalongkorn University, Bangkok, Thailand

6. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC

7. Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC

Abstract

Background High-grade inflammation represents a critical contribution to the onset of depression and might be manageable by physical activity (PA). Nevertheless, no study has examined synergistic interactions of insufficient PA and high values of the systemic immune-inflammation index (SII) on psychological problems. Objective We investigated independent and synergistic interactions of insufficient PA and high SII levels on stress, anxiety, and depression in T2DM patients. Methods A cross-sectional research design with 294 T2DM patients was conducted. An XP-100 automated hematology analyzer was used to evaluate inflammatory biomarkers. Depression, Anxiety, and Stress Scale-21 items and a standardized questionnaire about PA were respectively used to measure psychological problems and metabolic equivalent of task (MET)-h/week. Results A multiple linear regression demonstrated that patients with insufficient PA were significantly more likely to have higher stress ( β = 1.84, 95% confidence interval (CI) = 1.03–2.65), anxiety ( β = 1.88, 95% CI = 1.81–2.96), and depression ( β = 2.53, 95% CI = 0.82–4.24) than those with active PA. A high SII level was a key predictor and was most strongly associated with stress ( β = 2.61, 95% CI = 2.02–3.20), anxiety ( β = 3.16, 95% CI = 2.37–3.94), and depression ( β = 3.72, 95% CI = 2.49–4.96) compared to those who had low SII levels. Notably, additive interaction results showed that combining insufficient PA and a high SII level had a significantly escalated 1.71-fold risk of stress, 1.82-fold risk of anxiety, and 2.69-fold risk of depression. Conclusions Active PA and a low SII had a positive synergistic effect of decreasing psychological problems.

Funder

Postdoctoral Fellowship, Ratchadapisek Somphot Fund, Chulalongkorn University

the Ministry of Education, Culture, Research, and Technology, Indonesia.

the Ministry of Science and Technology, Taiwan

Publisher

SAGE Publications

Subject

Research and Theory

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3