Pre-exposure prophylaxis use among female sex workers in Gulu city, Uganda: a community-based cross-sectional study-Reference-Cited by-同舟云学术

Pre-exposure prophylaxis use among female sex workers in Gulu city, Uganda: a community-based cross-sectional study

Published:2023-01 Issue: Volume:10 Page:
ISSN:2049-9361
Container-title:Therapeutic Advances in Infectious Disease
language:en
Short-container-title:Therapeutic Advances in Infection

Author:

Bongomin Felix¹^ORCID,Kibone Winnie²^ORCID,Okot Jerom³,Ouma Simple⁴⁵,Madraa Grace⁶,Ojara Francis Williams⁷,Musoke David⁷,Pebolo Pebalo Francis⁸

Affiliation:

1. Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, P.O. Box 166, Gulu, Uganda

2. School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda

3. Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda

4. The AIDS Support Organization, Kampala, Uganda

5. The Institute of Clinical Trials and Methodology, University College London, London, UK

6. Department of Rural Development and Agri-Business, Faculty of Agriculture, Gulu University, Gulu, Uganda

7. Department of Pharmacology and Therapeutics, Faculty of Medicine, Gulu University, Gulu, Uganda

8. Department of Reproductive Health, Faculty of Medicine, Gulu University, Gulu, Uganda

Abstract

Background: Pre-exposure prophylaxis (PrEP) is an important intervention for reducing the risk of HIV transmission among high-risk populations such as female sex workers in Africa, where HIV prevalence remains high. We aimed to assess the use of PrEP among female sex workers in Gulu, Uganda. Methods: In this community-based cross-sectional study, we included HIV-negative female sex workers purposely selected from hotspots within Gulu city, Uganda between February and March 2023. A semi-structured questionnaire was administered to collect data on sociodemographic characteristics, reproductive data, sexual practices, and self-reported PrEP use in the past 3 months. Symptoms of depression were screened using Patient Health Questionnaire-2 tool. Predictors of PrEP use was determined using modified Poisson regression analysis model. p < 0.05 was considered statistically significant. Results: We enrolled 273 female sex workers with a median age of 27 (interquartile range: 24–32) years. Overall, 181 (66.3%) participants used PrEP. PrEP use was associated with; regular source of income beside sex work [adjusted prevalence ratio (aPR): 3.7, 95% confidence interval (CI): 2.11–6.35, p < 0.001], being in a polygamous marriage (aPR: 6.9, 95% CI: 1.32–35.77, p = 0.022), practicing sex work in both rural and urban areas (aPR: 2.5, 95% CI: 1.49–4.35, p < 0.001), having symptoms of depression (aPR: 3.3, 95% CI: 1.43–7.74, p = 0.005), and use of postexposure prophylaxis (PEP) in the past 12 months (aPR: 0.31, 95% CI: 0.17–0.59, p < 0.001). Conclusion: Almost two in three of the female sex workers in Gulu city were currently using PrEP. Previous use of PEP was associated with lower use of PrEP. These findings suggest the need for targeted interventions to increase PrEP uptake and decrease HIV acquisition in this high-risk population among female sex workers, especially those with low income and limited access to healthcare.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Infectious Diseases

Link

http://journals.sagepub.com/doi/pdf/10.1177/20499361231199550

Reference44 articles.

1. WHO. HIV and AIDS, https://www.who.int/news-room/fact-sheets/detail/hiv-aids (2022, accessed 1 April 2023).

2. Preference and uptake of different community-based HIV testing service delivery models among female sex workers along Malaba-Kampala highway, Uganda, 2017

3. UNAIDS. Geneva: Joint United Nations Programme on HIV/AIDS 2022, https://www.unaids.org/sites/default/files/media_asset/data-book-2022_en.pdf (accessed 1 April 2023)

4. “When they know that you are a sex worker, you will be the last person to be treated”: Perceptions and experiences of female sex workers in accessing HIV services in Uganda

5. WHO. Post-exposure prophylaxis to prevent HIV infection Joint, WHO/ILO guidelines on post-exposure prophylaxis (PEP) to prevent HIV infection. Geneva, Switzerland: World Health Organisation, 2007.