Everolimus in poorly differentiated neuroendocrine carcinoma of unknown primary: A case report-Reference-Cited by-同舟云学术

Everolimus in poorly differentiated neuroendocrine carcinoma of unknown primary: A case report

Published:2022-01 Issue: Volume:10 Page:2050313X2211069
ISSN:2050-313X
Container-title:SAGE Open Medical Case Reports
language:en
Short-container-title:SAGE Open Medical Case Reports

Author:

Bou Zerdan Maroun¹^ORCID,Hamouche Ramzi²,Bouferraa Youssef³,Chouairy Camil⁴,Gholam Dany⁵

Affiliation:

1. Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, USA

2. Yale-Waterbury Internal Medicine Residency Program, Waterbury, CT, USA

3. Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA

4. Department of Pathology, Saint George Hospital University Medical Center, Beirut, Lebanon

5. Department of Hematology and Oncology, Saint George Hospital University Medical Center (SGHUMC), Beirut, Lebanon

Abstract

Malignancies with unknown primaries contribute to a small yet significant percentage of overall tumors. Neuroendocrine carcinomas, a rare disease with a poor prognosis, have been known to present as an unknown primary. Treatment consists of cytotoxic chemotherapy but given the latter’s high toxicity profile new treatment options are being explored. In this case report, we describe a case of a patient with poorly differentiated neuroendocrine carcinoma of unknown primary treated with compassionate oral everolimus after his refusal of intravenous chemotherapy.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/2050313X221106987

Reference24 articles.

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5. The High-grade (WHO G3) Pancreatic Neuroendocrine Tumor Category Is Morphologically and Biologically Heterogenous and Includes Both Well Differentiated and Poorly Differentiated Neoplasms

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