Implication of the Nutritional and Nonnutritional Factors in the Context of Preservation of Cognitive Performance in Patients With Dementia/Depression and Alzheimer Disease

Author:

Aliev Gjumrakch12,Ashraf Ghulam Md3,Kaminsky Yury G.4,Sheikh Ishfaq Ahmed3,Sudakov Sergey K.5,Yakhno Nikolay N.6,Benberin Valery V.7,Bachurin Sergey O.8

Affiliation:

1. GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA

2. School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, GA, USA

3. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

4. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russian Federation

5. P.K. Anokhin Research Institute of Neurological Disorders, Russian Academy of Medical Sciences (RAMS), Moscow, Russian Federation

6. Department of Neurological Disorders, I.M. Sechenov Moscow State Medical University, Moscow, Russian Federation

7. Medical Center of the Administration of the President of the Republic of Kazakhstan, Astana, Kazakhstan

8. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russian Federation

Abstract

It has been postulated that Alzheimer disease (AD) is a systemic process, which involves multiple pathophysiological factors. A combination of pharmacotherapy and nonpharmacological interventions has been proposed to treat AD and other dementia. The nonpharmacological interventions include but are not limited to increasing sensory input through physical and mental activities, in order to modify cerebral blood flow and implementing nutritional interventions such as diet modification and vitamins and nutraceuticals therapy to vitalize brain functioning. This article highlights the recent research findings regarding novel treatment strategies aimed at modifying natural course of the disease and delaying cognitive decline through simultaneous implementation of pharmacological and nonpharmacological modulators as standardized treatment protocols.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

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